2-Iodoaniline CAS 615-43-0

What 2-Iodoaniline Is

2-Iodoaniline is an aniline carrying an iodine atom at the ortho position, sold as white to light brown crystalline needles or powder. In synthesis the carbon-iodine bond is the reactive site used in cross-coupling reactions to attach aryl and heteroaryl groups, and the adjacent amino group is diazotized, acylated or cyclized to build indoles, benzimidazoles and other nitrogen ring systems. UATChem offers standard material around 98% by GC or HPLC for pharmaceutical, dye and agrochemical intermediate work, with higher assay lots available for sensitive routes. It is insoluble in water and is handled in organic solvent systems.

Color, Purity and Light Protection

Iodinated anilines darken on exposure to light and air over time, so lots can range from near white through yellow to light brown and still meet specification. Assay by GC or HPLC, not visual color, is the acceptance criterion, and the COA reports measured purity and related substances. To slow darkening, material is packed in light-proof foil or lined bags and drums, and stock is kept cool, dry, sealed and out of direct light. High-purity or longer-dated lots can be supplied in smaller foil packs suited to refrigerated storage.

Pharmaceutical, Dye and Fine Chemical Uses

• Pharmaceutical intermediates. The iodine handles cross-coupling to add ortho-amino aryl groups, while the amino group cyclizes into indoles, benzimidazoles, quinazolines and other nitrogen heterocycles used in active ingredient routes.
• Dyes and pigments. A halogenated aniline intermediate for azo and functional dye synthesis where an ortho-iodo group is carried into later steps.
• Agrochemicals and custom synthesis. Used in crop protection intermediates and as a catalog building block for contract research and fine chemical development.

Typical Specifications

The table shows a standard 98% lot; higher assay, specific related-substance limits and particle or pack forms are available on request.

Packaging, Documents and Ordering

• Packed light-proof in 5 kg foil bags for samples and trials, 25 kg paper bags and 50 kg fiber drums for regular orders, and 1000 kg FIBC bags for production volumes; keep containers cool, dry, sealed and away from direct light.
• Classed as harmful and irritant (GHS Xn/Xi), the material can be harmful by inhalation, skin contact or ingestion and irritates the eyes, skin and respiratory tract, so gloves, goggles, a dust mask and ventilation are used; hazard labels and transport class follow the SDS for each order.
• Every lot ships with a COA showing GC or HPLC assay, melting point, related substances and appearance, together with SDS, and samples through to repeat tonnage orders are supported by UATChem. For a quote, send the CAS, target purity, quantity, packing preference and destination port.

FAQ

Q: Why does 2-iodoaniline arrive yellow or light brown?

A: Iodinated anilines darken under light and air, so near white to light brown is normal; accept by GC or HPLC assay, not color.

Q: What purity and pack sizes do you offer for 2-iodoaniline?

A: Around 98% by GC or HPLC, from 5 kg foil bags to 25 kg bags, 50 kg drums and 1000 kg FIBC lots, higher grades available.

Q: What is 2-iodoaniline mainly used for?

A: The iodine supports cross-coupling and the amino group builds nitrogen heterocycles for pharma, dye and agrochemical routes.