Azilsartan CAS 147403-03-0
Azilsartan (CAS 147403-03-0) is a white to off-white crystalline API in the ARB class — the angiotensin II receptor blockers used to treat hypertension. This page supplies the free acid, not the medoxomil prodrug: it is the defined step from which azilsartan medoxomil and finished tablets are built. UATChem supplies 99.0% min (HPLC) azilsartan in 1 kg aluminium foil bags for trials and 25 kg fibre drums for production, with COA, HPLC trace and DMF documentation on every order.
- CAS: 147403-03-0
- EINECS: 620-721-3 (verify against COA)
- Synonyms: Azilsartan free acid; 2-Ethoxy-1-[[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
- Molecular Formula: C25H20N4O5
- Molecular Weight: 456.45
- Appearance: White to off-white crystalline powder
- Assay (HPLC): 99.0% min
- Total Impurities: 1.0% max
- Melting Point: 200 – 205 °C
- Packaging: 1 kg foil bag / 25 kg fibre drum
The Free-Acid API
Azilsartan is an angiotensin II receptor blocker developed by Takeda, acting on the AT1 receptor behind blood-pressure control. The molecule carries an oxadiazolone ring rather than the tetrazole common to older sartans, which is part of what distinguishes its binding profile. Marketed oral products use the ester prodrug azilsartan medoxomil, which converts to azilsartan during absorption. This page supplies the free-acid API, the defined step from which the prodrug and finished formulations are made.
Applications
- Azilsartan medoxomil synthesis. Key starting point for producing the ester prodrug used in commercial ARB tablets; the free acid feeds the esterification step with defined purity.
- Hypertension formulation development. API for oral solid development, covering tablet and capsule prototypes, dissolution studies and bioavailability work on the ARB molecule.
- Combination therapy R&D. Supports fixed-dose combination programs with chlorthalidone and amlodipine, the combination lines approved in major markets.
- Regulatory and QC use. Characterized 99.0% lots serve as working reference in quality control and analytical method development, backed by DMF documentation for filings.
Specifications
| Test Parameter | Acceptance Limit |
|---|---|
| Assay (HPLC) | 99.0% min |
| Total Impurities | 1.0% max |
| Single Unknown Impurity | 0.1% max |
| Loss on Drying | 0.5% max |
| Residue on Ignition | 0.1% max |
| Heavy Metals (as Pb) | 10 ppm max |
| Arsenic | 2 ppm max |
| Melting Point | 200 – 205 °C |
Storage, Handling and Packaging
- Store tightly sealed, light-resistant containers in a cool, dry warehouse below 25 °C, away from sunlight, heat and strong oxidizers.
- Inspect drums on receipt and reseal after sampling; 24-month shelf life in original packaging.
- Trial orders from 1 kg in aluminium foil bags; production in 25 kg fibre drums with PE liners; custom packaging and private labelling on request.
- COA with HPLC trace, TDS and SDS standard; DMF access and Certificate of Origin available for regulatory work; quotes within one working day. State the quantity and destination in your RFQ.
FAQ
Q: What is azilsartan used for?
A: It treats hypertension as an ARB; marketed tablets use its medoxomil prodrug.
Q: Is this the free acid or the medoxomil?
A: This is the free acid, the API step used to make azilsartan medoxomil.
Q: What purity is supplied?
A: 99.0% min by HPLC, total impurities under 1.0%, single unknown under 0.1%.
Q: What documentation is available?
A: COA with HPLC trace, TDS, SDS and DMF are available for regulatory filing.
Q: What is the minimum order?
A: Trial lots from 1 kg foil bags; production orders in 25 kg fibre drums.
Related products
Ready to Source? Talk to Our Engineers
Industrial Chemical Raw Materials, Factory-Direct — Quote Within 1 Hour
Stable high-purity supply, flexible packaging and complete compliance documentation for your formulations — exporting worldwide since 2006.
- 1000+Products
- 200+QC Protocols
- 7–15Days Delivery
- Factory-Direct Pricing
- COA / TDS / SDS Included
- Free Samples for Testing
- ISO 9001 Certified