Alpha Lipoic Acid CAS 1077-28-7

Alpha Lipoic Acid (ALA, thioctic acid, CAS 1077-28-7) is a yellow crystalline, sulfur bearing antioxidant that works in both water and fat. The body uses the natural R form, while most commercial material is synthetic racemic R/S powder, and the R form is available on request. It melts low, is nearly insoluble in water but dissolves in alcohol and alkaline solution, so direct compression granules and stabilized or encapsulated forms are offered for tablets, capsules and drinks. Most output goes into supplements for antioxidant, nerve and metabolic support, with cosmetic serums and pharmacopoeia grade injection or tablet material as further outlets. UATChem supplies ALA powder and granules in 25 kg bags or fiber drums and bulk bags; send the grade, form, quantity and destination for a quote with COA and SDS.

  • CAS: 1077-28-7 (racemic); R form 1200-22-2
  • EC Number: 214-071-2
  • Synonyms: Thioctic acid; ALA; 1,2-dithiolane-3-pentanoic acid
  • Molecular Formula: C₈H₁₄O₂S₂
  • Molecular Weight: 206.33
  • Appearance: Yellow crystalline powder, slight odor
  • Melting Point: 60 to 62 °C (racemic)
  • Solubility: Nearly insoluble in water; soluble in alcohol / alkali
  • Character: Amphiphilic sulfur antioxidant, R and R/S forms
  • Form: Powder, direct compression granules, stabilized / encapsulated
  • Use: Antioxidant supplements, cosmetics, pharmacopoeia grade
  • Packaging: 25 kg bag / fiber drum; FIBC, custom packing available
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What Alpha Lipoic Acid Is

Alpha lipoic acid, also called thioctic acid, is an organosulfur carboxylic acid built around a 1,2-dithiolane ring, sold as a yellow crystalline powder with a slight characteristic odor. The ring and the acid chain give it both water and fat soluble character, and the molecule supports redox balance in supplement and cosmetic formulas. The natural and biologically active enantiomer is R-(+)-alpha lipoic acid; standard synthetic output is the racemic R/S mixture sold under CAS 1077-28-7, and the R form (CAS 1200-22-2) can be ordered for premium lines. The powder melts around 60 to 62 °C, barely dissolves in cold water and dissolves in alcohol and alkaline media, so heat, light and moisture are controlled during storage. UATChem supplies food, supplement and pharmacopoeia grades as powder, direct compression granules or stabilized granules, with assay and form confirmed on the COA.

Supplements, Cosmetics and Pharma Use

  • Dietary supplements. Made into capsules, tablets and blend powders for antioxidant, nerve and metabolic support, often in blood sugar, weight and energy formulations.
  • Functional food and drinks. Stabilized or encapsulated granules improve solubility and shelf life in beverages and functional food products.
  • Cosmetics. Listed as Thioctic Acid, an antioxidant and conditioning ingredient in anti-aging serums, emulsions and skin or hair care formulas.
  • Pharmaceutical. Pharmacopoeia grade thioctic acid for injection and tablet preparations, with the R enantiomer supplied for premium lines.

Energy, heart and nerve formula brands also pair ALA with fermented D-ribose in antioxidant and sports nutrition blends.

Typical Specifications

Food, supplement and pharmacopoeia grades differ in assay, particle size and loss on drying, with compendial material available on request; values are reported on the COA for each lot, and the physical constants below identify the material.

Parameter Typical Value
Appearance Yellow crystalline powder, slight odor
Melting Point 60 to 62 °C (racemic)
Solubility Nearly insoluble in water; soluble in alcohol / alkali
Forms Powder; direct compression granules; stabilized / encapsulated
Enantiomer Racemic R/S (1077-28-7); R form (1200-22-2) on request
Grade Food / supplement / pharmacopoeia, COA per lot

Packaging, Documents and Ordering

  • Packed in 25 kg paper bags or fiber drums with liner, in 1000 kg FIBC bags and in foil sample sachets; packs stay sealed, light protected, cool, dry and away from oxidizers, with temperature control advised for long haul because the powder melts low and is heat sensitive.
  • Alpha lipoic acid is a food and supplement ingredient safe within normal use, with standard dust protection for the yellow powder. Every lot carries a COA with assay, particle size, loss on drying, melting point and rotation, together with TDS and SDS; food or pharmacopoeia compliance, R enantiomer statements and samples can be discussed at inquiry.
  • For a quote, UATChem needs the grade (food, supplement or pharmacopoeia), enantiomer (racemic or R), form (powder, direct compression or stabilized granules), quantity, packing and destination port.

FAQ

Q: What is alpha lipoic acid used for?

A: It is a sulfur antioxidant in capsules and tablets for nerve and metabolic support, used in cosmetics, food and injections.

Q: What is the difference between R-alpha lipoic acid and racemic ALA?

A: R-(+)-ALA is the natural active enantiomer (CAS 1200-22-2); standard ALA is the R/S racemate (CAS 1077-28-7), R on request.

Q: Is alpha lipoic acid soluble in water?

A: Nearly insoluble in water, it dissolves in alcohol and alkali, so stabilized granules suit drinks and DC granules for tablets.

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