L-Hydroxyproline (Hyp) CAS 51-35-4

What L-Hydroxyproline Is

L-hydroxyproline, or trans-4-hydroxy-L-proline, is a hydroxylated proline molecule and one of the imino acids rather than a standard amino acid. It is a white to off-white crystalline powder that dissolves freely in water, and it is best known as the marker amino acid of collagen, formed in the body when proline is hydroxylated with vitamin C. The hydroxyproline content of a protein is used as a measure of its collagen level. Commercial material for export is produced mainly by non-animal fermentation or enzymatic conversion, avoiding gelatin derived sources for vegan and regulated markets. UATChem supplies food, supplement and pharmacopoeia grades, with assay, loss on drying and rotation reported on the COA for each lot.

Collagen Supplements, Pharma and Cosmetics Use

• Collagen and beauty supplements. Used in collagen, skin and joint support powders, capsules and beauty blends, often paired with glycine, proline and vitamin C.
• Functional food and drinks. Added to beauty and collagen functional foods, beverages and fortified nutrition products.
• Pharmaceutical. A pharmacopoeia grade ingredient for amino acid infusion and compound preparations, and a chiral building block in carbapenem and ACE inhibitor synthesis.
• Cosmetics and research. A moisturizing and skin conditioning ingredient in personal care, and a component in cell culture and biochemical reagents.

Collagen blends commonly pair hydroxyproline with glycine, the most abundant amino acid in collagen; UATChem also supplies glycine powder for the same beauty and nutrition formulations.

Typical Specifications

Food, supplement and pharmacopoeia grades differ in assay, loss on drying and particle size, with compendia such as AJI, USP or EP met on request; values are reported on the COA for each lot, and the physical constants below identify the material.

Packaging, Documents and Ordering

• Packed in 25 kg paper bags or fiber drums with liner and in 1000 kg FIBC bulk bags; packs stay sealed, dry and cool, protected from moisture during storage and transit.
• L-hydroxyproline is a food amino acid safe within normal use and essentially non-toxic, with standard dust protection in handling. Every lot carries a COA with assay, loss on drying, specific rotation and particle size, together with TDS and SDS; food or pharmacopoeia compliance and non-animal or vegan statements can be discussed, and samples are supported.
• For a quote, UATChem needs the grade (food, supplement or pharmacopoeia), quantity, packing and destination port.

FAQ

Q: What is L-hydroxyproline used for?

A: It is the collagen marker in skin and joint supplements and beauty blends, plus functional food, cosmetics and drug synthesis.

Q: Is L-hydroxyproline vegan and non-animal?

A: Yes, export material is made mainly by non-animal fermentation, avoiding gelatin sources for vegan and clean label products.

Q: How is L-hydroxyproline related to collagen?

A: Hydroxyproline stabilizes the collagen helix, and its level in a protein is used as a measure of collagen content.